Evaluation of serum Inhibin-B in polycystic ovarian syndrome (PCOs), premature ovarian failure (POF) and related with obese infertility, Case-Control study

Zahraa Abd Al-Amir Jalil  Mamitha; Abeer Cheaid Yousif  Al-Fatlawi; Manal  Hamdan

doi:10.69923/ewnpb460

Evaluation of serum Inhibin-B in polycystic ovarian syndrome (PCOs), premature ovarian failure (POF) and related with obese infertility, Case-Control study

Authors

Zahraa Abd Al-Amir Jalil University of kerbala / Collage of applied medical sciences/clinical laboratory department Author
Abeer Cheaid Yousif Al-Fatlawi University of kerbala / Collage of applied medical sciences/clinical laboratory department Author
Manal Nasih Ahmed Hamdan University of Kerbala Author

DOI:

https://doi.org/10.69923/ewnpb460

Keywords:

Inhibin-B, Polycystic Ovarian Syndrome (PCOS), Premature Ovarian Failure (POF)

Abstract

Infertility is the failure to become pregnant after 1 year or more of frequent, unprotected sexual intercourse without taking contraceptives. It has two categories primary and secondary infertility. study aimed to use Inhibin-B for the prognosis of polycystic ovarian syndrome (PCOs) and premature ovarian failure (POF) in female infertility patients. The study was designed A case-control study, including (120) females with a range of age (20-40) years, subdivided into two groups (60) healthy apparent females used as control, and (60) infertile females distributed between (37 PCOs), (23 POF). Inhibin-B serum was measured using an enzyme-linked immunosorbent assay (ELISA). The results showed that the BMI level of patients was (30.95 ± 3.42) as compared to control (27.9 ± 1.93). In PCOs according to age above and under (35 years) showed a significant increase (p≤0.0001) in Inhibin-B (273.55 ± 75.25), (234.91±52.43) respectively, and a decrease in POF (18.96 ±1.21). Inhibin-B (95% CI: 0.907 - 1.000; P-value: 0.001; Cutoff Point: 77.347; AUC: 95.417%) with Sensitivity to Specificity (91.667% - 98.333%); and Accuracy: 95.000%. The study concluded that the increase in the levels of serum Inhibin-B could be considered a useful indicator of the likelihood that a female of reproductive age will have PCOs and POF that are diagnosed by the Rotterdam standards.

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Author Biographies

Zahraa Abd Al-Amir Jalil , University of kerbala / Collage of applied medical sciences/clinical laboratory department

MSc. Student in College of Applied medical science Department of Clinical Laboratories, University of Kerbala, Kerbala, Iraq

Received BSc Degree in Department of Clinical Laboratories, College of Applied Medical Science, from University of Kerbala/Kerbala/Iraq (2021)
Abeer Cheaid Yousif Al-Fatlawi, University of kerbala / Collage of applied medical sciences/clinical laboratory department

Work Address: Kerbala University / College of applied medical sciences / clinical laboratory department PhD. physiology, College of Science, Al-Kufa University (2015)

MSc. Biology, physiology, Collage of Education, kerbala University (2009)

BSc. Biology, College of Education, Dep. Biology/ kerbala University (2002)
Manal Nasih Ahmed Hamdan , University of Kerbala

MSc. Student in the College of Applied Medical Science Department of Clinical Laboratories, University of Kerbala, Kerbala, Iraq, Received BSc Degree in Department of Clinical Laboratories, College of Applied Medical Science, from University of Kerbala/Iraq (2021) Email: zahraa.jalil@s.uokerbala.edu.iq

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Published

30-06-2025

Issue

Vol. 2 No. 2 (2025): Volume 2, Issue 2

Section

Research Articles

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How to Cite

[1]

Z. A. A.-A. J. . Mamitha, A. C. Y. . Al-Fatlawi, and M. . Hamdan, “Evaluation of serum Inhibin-B in polycystic ovarian syndrome (PCOs), premature ovarian failure (POF) and related with obese infertility, Case-Control study”, IJApSc, vol. 2, no. 2, pp. 25–31, Jun. 2025, doi: 10.69923/ewnpb460.