Azo Coupling Reaction for Spectrophotometric Determination of Sulfanilamide Using β -Naphthol as a Reagent

Authors

  • Nabaa Malh Ahmad University of Diyala Author
  • Iqbal Salman Muhammd University of Diyala Author

DOI:

https://doi.org/10.69923/x09a3a81

Keywords:

Spectrophotometric, Diazotization, PharmaceuticalPreparations,Sulfanilamide,β-Naphthol

Abstract

This research is based on one simple and good method for determining sulfanilamide in its pure state and in pharmaceutical preparations. Spectrophotometric determination of Sulfanilamide using the azo coupling reaction in an aqueous solution and several standard solutions were prepared. The optimal conditions were also studied. The effects of the type of acid and its volume, the influence of the base type and its volume, the effect of reagent volume (100 µg/ml), the effect of reaction time on the color stability of the product, the effect of adding sequence, the solvent effect, and the effect of temperature on the formation and stability of the colored product. The product for the Sulfanilamide drug is auburn at a wavelength of 489 nm; the method obeyed Beer's law in a range of concentrations ranging from 1–12 µg/ml; and the molar absorptivity was 28840.76 L/mol.cm. Sandal's sensitivity (0.00091 μg/cm), detection limit (0.2472 µg/ml), correlation coefficient value 0.9984, and RSD% value 0.01365, By applying the method to a pharmaceutical preparation containing Sulfanilamide, the recovery value ranged between 102.1306%.

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Author Biographies

  • Nabaa Malh Ahmad, University of Diyala

    Naba Malh Ahmad is Master's student at the College of Education for Pure Sciences at the University of Diyala. she obtained a bachelor’s degree in chemistry from College of Education for Pure Sciences at the University of Diyala. 2020. She can be contacted at email:   nabaa.m.ahmad.msc23@uodiyala.edu.iq

  • Iqbal Salman Muhammd, University of Diyala

    Dr. Iqbal Salman Muhammd is an associate professor at the College of Education for Pure Sciences at the University of Diyala. He obtained a bachelor’s degree in chemistry from University of Baghdad and a master’s degree from the University of Anbar, College of Sciences. He obtained a doctorate from the University of Baghdad , College of Science for Girls, , in the specialty of Analytical chemistry. His areas of  research are:  Chemistry includes Analytical aspects and includes the diagnosis of complexes and their applications. She has published several scientific papers in national, and international conferences and journals. He can be contacted at email : Ikbalsalman696@gmail.com

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Published

09/30/2024

Issue

Vol. 1 No. 2 (2024)

Section

Articles

License

Copyright (c) 2024 Iraqi Journal for Applied Sciences

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References

Marshall,G.C.and H.W.Ohm 1987 .Yield responses of 16 winter wheat cultivars to row spacing and seeding rate .Agronomy Journal .79:1027-1030

How to Cite

[1]
“Azo Coupling Reaction for Spectrophotometric Determination of Sulfanilamide Using β -Naphthol as a Reagent”, IJApSc, vol. 1, no. 2, pp. 46–55, Sep. 2024, doi: 10.69923/x09a3a81.

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