Spectrophotometric Determination of Sulfamethazole Drug by Using Azo Coupling Reaction

Authors

  • Noor Ali Hussein Alwan University of Diyala Author
  • Iqbal S. Mohammed University of Diyala Author

DOI:

https://doi.org/10.69923/IJAS.2024.010110

Keywords:

Spectrophotometric, Diazotization, Pharmaceutical Preparations, Sulfamethzole, β-Naphthol

Abstract

This research is based on one simple and good method for determining in their pure sta Sulfamethaxazone te and in pharmaceutical preparations. Spectrophotometric determination of using the azo co Sulfamethzole upling reaction in an aqueous solution and several standard solutions were prepared. The optimal conditions were also studied Effect of the type of acid and its volume, the influence of the base type and its volume, Effect of reagent volume (100 µg/ml), Effect of reaction time is color Product stability and effectiveness adding equence, Solvent effect, and Effect of temperature on the formation and the stability of colored product. The product for the Sulfamethzole drug is Orange at the wavelength of 489nm, the This method follows Beer's law in one respect of concentrations ranging from (1-12 µg/ml), and is the molar absorbance (39534.061 L/mol.cm). Sandal's sensitivity (0.0009 μg/cm), detection limit (0.3539 µg/ml), correlation coefficient value 0.999, and RSD% value 0.0010925, By applying the method to a pharmaceutical preparation containing Sulfamethzole , Sulfamethaxazone he recovery value ranged between 100.388075%.

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Author Biographies

  • Noor Ali Hussein Alwan, University of Diyala

    Ali Hussein is a Master's student at the College of Education for Pure Sciences at the University of Diyala. she obtained a bachelor’s degree in chemistry from College of Education for Pure Sciences at the University of Diyala. 2019 and she is a teacher at Sumaya middle school for Girls. 

  • Iqbal S. Mohammed, University of Diyala

    Dr. Iqbal Salman Muhammd is an associate professor at the College of Education for Pure Sciences at the University of Diyala. He obtained a bachelor’s degree in chemistry from University of Baghdad and a master’s degree from the University of Anbar, College of Sciences. He obtained a doctorate from the University of Baghdad , College of Science for Girls, , in the specialty of Analytical chemistry. His areas of  research are:  Chemistry includes Analytical aspects and includes the diagnosis of complexes and their applications. He has published several scientific papers in national, and international conferences and journals. He can be contacted at email : 

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Published

06/30/2024

Issue

Section

Articles

How to Cite

[1]
“Spectrophotometric Determination of Sulfamethazole Drug by Using Azo Coupling Reaction”, IJApSc, vol. 1, no. 1, pp. 88–101, Jun. 2024, doi: 10.69923/IJAS.2024.010110.

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