Determination of valsartan drug by ion pair complex formation method in tablet form

Authors

  • Qaaed Baker Ministry of Education Author
  • Eman Thiab Al-Samarrai University of Samarra Author

DOI:

https://doi.org/10.69923/851hfy94

Keywords:

Ion pair ,Pharmaceutical ,Spectrophotometer, Tablets, Valsartan

Abstract

A rapid, simple, sensitive, spectroscopic, ion pair complex method was developed for valsartan (VAL ) in pharmaceutical forms. Resazurin dye was used to form an ion pairing complex with the drug valsartan. analytical characteristics of the proposed method are Beer’s law range =10-60 (μg/mL), correlation coefficient  (R2) = 0.9976 , limit of detection (LOD) = 0.1076(µg/mL), limit of quantification (LOQ) = 0.3261 (µg/mL), recovery percentage (%Rec) = (101.9626% - 95.6074%), relative standard deviation (%RSD)= 0.6188% - 0.7148%, Molar absorption (ε)= 4659.85(L/mol.cm), Sandell's index(S) = 0.093458(μg/cm2),at wavelength 495 nm . The results showed high accuracy and precision of the proposed quantification method for the valsartan drug , and it was of high accuracy and consistent.

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Author Biographies

  • Qaaed Baker, Ministry of Education

     Qaaed Baker Ali    Master's student in the Chemistry Department, Collage of Education, Samarra University. His research areas are in the field of analytical chemistry and how to estimate medical drugs. One research was published in a journal within the Scopus archives, and another research was published in a conference indexed within the Scopus conferences. He received a letter of thanks from the President of the University of Samara. He can be contacted at email: qaed_ali@uosamarra.edu.iq

  • Eman Thiab Al-Samarrai, University of Samarra

    Dr. Eman Thiab Al-Samarrai is an Associate Professor at the College of Education, University of Samarra, Iraq. She received a B.Sc. degree in Chemistry from the University of Samarra and an M.Sc. degree from the University of Samarra. Her research areas are in the field of analytical chemistry and how to estimate medical drugs. She has published many scientific papers in national and international conferences and journals. She can be contacted at emil: eman.dh@uosamarra.edu.iq

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Published

09/30/2024

Issue

Vol. 1 No. 2 (2024)

Section

Articles

License

Copyright (c) 2024 Iraqi Journal for Applied Sciences

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References

Marshall,G.C.and H.W.Ohm 1987 .Yield responses of 16 winter wheat cultivars to row spacing and seeding rate .Agronomy Journal .79:1027-1030

How to Cite

[1]
“Determination of valsartan drug by ion pair complex formation method in tablet form”, IJApSc, vol. 1, no. 2, pp. 56–65, Sep. 2024, doi: 10.69923/851hfy94.

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