Examining Metal Complexes Formed from New Schiff Base ‎Ligand ‎Derived from Benzene Carbaldehyde: Evaluation of Anti-‎biofilm and ‎Anti-bacterial Properties

Authors

  • Enass Jasim Waheed University of Baghdad Author

DOI:

https://doi.org/10.69923/ajdjnb33

Keywords:

benzenecarbaldehyde, ‎ Schiff base, Antibiofilm, ‎Antibacterial ‎

Abstract

One of the most difficult tasks in modern medical societies is the process of identifying a cure for many infectious diseases caused by drug-resistant microbes. Therefore, it has become necessary to discover new compounds that work in this regard. The currently prepared Schiff base, derived from thiazole, has a biological activity against bacteria and biofilms and its activity increases when it is associated with copper, zinc and platinum ions and forms metal complexes. This study highlights the synthesis and evaluation of novel biological compounds as inhibitors of bacterial growth and biofilms. A three newly complexes are resulting from the reaction of a new Schiff base ligand (LC) with metal ions (Zn, Cu, Pt). The new ligand (LC) was prepared from the reaction of precursor (P) and benzenecarbaldehyde. The prepared compounds were characterized by 1H&13CNMR, FTIR, UV-Vis, Magnetic susceptibility, CHNS and Molar conductivity. It was determined that the anti-bacterial activity of the newly synthesized Lc and (Cu-Lc) was mightily significant towards more antibiotic-resistant bacteria and had low (MIC) values. Like that, anti-biofilm inhibitory of the same compounds showed 100% of clinical isolates of P. aeruginosa and S. aureus in 16 and 32 mg/ml respectively, whereas (Zn-Lc) were inhibited 100% in 4 mg/ml. On the other hand (Pt-Lc) inhibited 100 % in 2 mg/ ml. Good yield was obtained from the synthesis of new compounds from the starting material. They can be potential candidates as inhibitors of bacteria and biofilms.    

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Author Biography

  • Enass Jasim Waheed, University of Baghdad

    Dr. Enass Jasim Waheed is Assist. Prof. at the College of Education for Pure Sciences, Ibn -Al-Haitham, University of Baghdad she obtained a doctor’s degree in chemistry from College of Education for Pure Sciences, Ibn -Al-Haitham. 2016. Her areas of research are:    Chemistry includes organic and inorganic aspects and includes the characterization of complexes and their applications. She can be contacted at email:   enass.j.w@ihcoedu.uobaghdad.edu.iq

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Published

09/30/2024

Issue

Section

Articles

How to Cite

[1]
“Examining Metal Complexes Formed from New Schiff Base ‎Ligand ‎Derived from Benzene Carbaldehyde: Evaluation of Anti-‎biofilm and ‎Anti-bacterial Properties”, IJApSc, vol. 1, no. 2, pp. 66–76, Sep. 2024, doi: 10.69923/ajdjnb33.

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