Metabolic Mechanisms of Fat Accumulation and Effects of a Healthy Lifestyle Intervention on Obesity Indicators in Adults A Case-Control Study

Nour Shakir Rezaieg; Muthanna Mohammed Awad Saleh  Al-Dulaimi

doi:10.69923/gptexp61

Metabolic Mechanisms of Fat Accumulation and Effects of a Healthy Lifestyle Intervention on Obesity Indicators in Adults A Case-Control Study

Authors

Nour Shakir Rezaieg University of Anbar Author https://orcid.org/0009-0006-7870-2100
Al-Dulaimi University of Anbar Author https://orcid.org/0009-0004-6517-990X

DOI:

https://doi.org/10.69923/gptexp61

Keywords:

Obesity, Body Composition, Lifestyle Modification, Lipid profile, Metabolic indicators

Abstract

Obesity is a complex condition resulting from a long-term positive energy balance, in which energy intake exceeds energy expenditure, leading to excessive accumulation of adipose tissue. This study evaluated the impact of a six-month healthy lifestyle intervention on anthropometric, metabolic, and lipid parameters among obese adults. Participants were divided into three groups: obese individuals pre-intervention, the same group post-intervention, and normal-weight controls. Body composition was measured, and lipid profile and metabolic parameters were assessed before and after the intervention. The study was designed as a quasi-experimental longitudinal controlled study, done from 2024 to 2025. The intervention included a healthy lifestyle program designed for the obese group. The results showed significantly higher body composition and metabolic indices in the obese group compared to normal-weight individuals. Lipid profiles were significantly higher (P<0.05), with the exception of high-density lipoprotein, which was low in the obese group before the intervention. Post-intervention, a significant decrease was observed in body composition indicators, lipid profile, and metabolic indicators compared to the values recorded before the intervention. These values, however, remain higher than the levels of healthy individuals. High-density lipoprotein increased slightly post-intervention but did not reach the level of normal-weight individuals. The results reflect the positive effect of fat loss on reducing chronic inflammation associated with obesity and improving metabolic and lipid profiles, confirming the effectiveness of a healthy lifestyle in obesity management.

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Author Biographies

Nour Shakir Rezaieg, University of Anbar

Nour Shakir Rezaieg is a PhD student at the University of Anbar, Department of Biology, College of Education for Pure Sciences, Anbar, Iraq. She is a lecturer in Al-Anbar Secondary for Distinguished Boys. She holds a master’s degree in animal physiology and the academic title of lecturer. Her research interests include nutrition, the neurobiology of obesity, endocrinology, metabolic health, and the brain-gut axis. She can be contacted at email: nou23u1003@uoanbar.edu.iq
Al-Dulaimi , University of Anbar

Dr. Muthanna Mohammed Awad Saleh Al-Dulaimi is a professor at the University of Anbar, Department of Biology, College of Education for Pure Sciences, Anbar, Iraq. He holds a PhD in life sciences and animal physiology. His research interests include hematology, animal and human physiology, cancer epidemiology, endocrinology, oxidative stress, and antioxidants. He can be contacted at muthanna.awad@uoanbar.edu.iq.

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Published

30-12-2025

Issue

Vol. 2 No. 4 (2025): Volume 2, Issue 4

Section

Research Articles

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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This article is published by the Iraqi Journal for Applied Science (IJAS) under the Creative Commons Attribution 4.0 International License (CC BY 4.0).

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How to Cite

[1]

N. Shakir Rezaieg and M. M. A. S. . Al-Dulaimi, “Metabolic Mechanisms of Fat Accumulation and Effects of a Healthy Lifestyle Intervention on Obesity Indicators in Adults A Case-Control Study”, IJApSc, vol. 2, no. 4, pp. 30–43, Dec. 2025, doi: 10.69923/gptexp61.