Synthesis,Green Chemistry Method Characterization of CuFe5O8 Nanocomposite and Assessment of Its Prostate Cancer-Preventive Effects

Abstract

In this work, CuFe5O8 nanoparticles were prepared to utilize Origanum vulgare leaf extract in a novel, simple, and inexpensive procedure that incorporated three techniques: co-precipitation, ultrasound, and green chemistry. The following methods were used to characterize the produced nanoparticles: XRD, FT-IR, EDX, SEM, and DLS. The average particle size measured in the XRD was 45.101 nm, but the average particle size in the SEM was 64.17 nm. The DLS had particles with an average size of 924.4 nm simultaneously. The efficacy of the synthesised CuFe5O8 nanoparticles was evaluated against that of the medication Flutamide, which is administered to treat prostate cancer in Iraq using the PC3 cell line. The results demonstrated the nanoparticles' outstanding efficacy and superiority over the medication. In addition, they were distinguished by their lack of cytotoxicity when measured against the drug's toxicity on red blood cells in the toxicity screening test. If the results indicated that the drug Flutamide had a cell killing value of 6.51, 10.55, 27.69, 32.48, and 52.53) at 24 hours, as well as for CuFe5O8, respectively, the cell killing results were 33.69, 38.53, 46.42, 56.11, and 69.59)%  as well value IC50 = 88.46.