Effect of Pregnyl (HCG) on Histological Structure of Testes in Albino Mice

Abstract

Pregnyl is a placental hormone, produced mainly during the entire period of pregnancy, making it the vital sign for detecting pregnancy. The current study shed light on the effect of pregnyl on the histological structure of testes in Albino mice. The study included 15 mice, and the animals were divided into two groups. The first group included five mice, and the second group included ten mice. They were placed in separate cages with continuous monitoring and cleaning throughout the study. The first group was injected with Pregnyl at a concentration of 0.1 mg/kg and the second group at a concentration of 0.2 mg/kg for a period of 30 days. After the end of the experiment, the animals were sacrificed, dissected, and their testicles were removed for the purpose of histological study. The outcome of this study shows that the animals in the two empirical groups treated with Pregnyl showed changes in thickness of seminiferous tubules of the testis wall and their shrinkage, as their manifestation became wavy and offbeat. Furthermore, atrophy was noted in a few of the seminiferous tubules, as well as the sloughing and exhaustion of some germ cells and their accumulation in the lumen of seminiferous tubules. Additionally, degeneration was observed in some Sertolic cells.