Immunological and Metabolic changes in Iraqi Women Patient with Graves' disease

Abstract

Graves' disease, a common cause of hyperthyroidism, affects middle-aged individuals, affecting lipid metabolism. Risk factors include genetic, environmental, and immunological factors. The aim of the study was to examine the possible correlation between certain blood biomarkers in individuals with Graves' disease before and after undergoing therapy with radioactive iodine (RAI). Sixty grave’s disease patients, 30 of whom received radioiodine therapy, in addition to 30 healthy people as control with age range of (25-60) years old were enrolled in this study through their presence at the AL-Amal National Hospital for nuclear medicine in Baghdad. Blood samples were collected to evaluate the level lipid profile, C-reactive protein, complete blood count, sodium and calcium. Results showed highly significant (P≤0.01) decreased in lipid profile parameters and a significant increasing in C-reactive protein level in both groups, before and after treatment, but no relation was found between GD and sodium and calcium. Thyroid dysfunction had an obvious impact on lipid metabolism. Grave's disease decreases lipid levels and increases body metabolism. Also increase an inflammation in body leading to high CRP levels in patients. No relationship was found between electrolyte elements.