Synthesis, Characterization and Biological activity of new Metal Complexes Derived From 4-Phenyl-3-thiosemicarbazide

Eman Ahmed; Nasry Jassim Hussien Hussien; Siti Fairus M.Yusoff Yusoff

doi:10.69923/k2n0gm05

Synthesis, Characterization and Biological activity of new Metal Complexes Derived From 4-Phenyl-3-thiosemicarbazide

Authors

Eman Ahmed جامعة ديالى Author
Nasry Jassim Hussien Hussien University of Diyala Author https://orcid.org/0000-0002-0423-7692
Siti Fairus M.Yusoff Yusoff Universiti Teknologi Malaysia Author https://orcid.org/0000-0002-3470-4327

DOI:

https://doi.org/10.69923/k2n0gm05

Keywords:

Antibacterial, Activity, Metal Complexes, Synthesis

Abstract

The study involved the synthesis and characterization of the new compound 4-methoxy-N-(2-(phenylcarbamothioyl) hydrazine-1-carbonothioyl) benzamide (L). By combining the title ligand with metal ions of manganese (II), cobalt (II), and nickel (II), three transition metal complexes were synthesized. This reaction occurred through the combination of metal and ligand in a mole ratio of one-to-one utilizing ethanol as the solvent. The complexes generated have chemical formulas as follows: [LMnCl₂.H₂O], [LCoCl₂H₂O], and [LNiCl₂.H₂O]. A variety of physicochemical techniques have been utilized to demonstrate the entity of the predicted structure of the ligand and its metal complexes. including Fourier transform infrared spectroscopy, UV-Vis spectroscopy, (¹H and ¹³C)-NMR, elemental analysis (C, H, N, S), content of chloride, content of metal, m.p., the molar conductivity measurements, and also magnetic susceptibility. Based on spectral and analytical data, the isolation complexes for the manganese (II), cobalt (II), and nickel (II) exhibit a six-coordinate with a distorted octahedral geometry. The antibacterial activity of the complexes was investigated against (G+) and (G-) bacteria.

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Author Biographies

Nasry Jassim Hussien Hussien, University of Diyala

Dr. Nasry Jassim Hussien is a professor at the College of Education for Pure Sciences at the University of Diyala. He obtained a bachelor’s degree in chemistry from Al-Mustansiriya University and a master’s degree from the University of Technology, Department of Applied Sciences. He obtained a doctorate from the Malaysian University UKM, College of Science and Technology, FST, in the specialty of inorganic chemistry. His areas of research are: Chemistry includes organic and inorganic aspects and includes the diagnosis of complexes and their applications. He has published several scientific papers in national and international conferences and journals. He can be contacted at email: nasry.hussien@uodiyala.edu.iq
Siti Fairus M.Yusoff Yusoff, Universiti Teknologi Malaysia

Dr.Siti Fairus M.Yusoff received a Bachelor of Science (Pure Chemistry) from Universiti Teknologi Malaysia (2007) and a Doctor of Philosophy in the same field from the University of Bristol in the United Kingdom (2011). Currently, she is a senior lecturer at the Faculty of Science and Technology, Universiti Kebangsaan Malaysia. Her research focuses on the development of polymer and inorganic materials for different applications, such as wastewater treatment, agriculture, and biomedicine has published several scientific papers in national, and international conferences and journals. She can be contacted at email: sitifairus@ukm.edu.my

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Published

30-12-2025

Issue

Vol. 2 No. 4 (2025): Volume 2, Issue 4

Section

Research Articles

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How to Cite

[1]

E. Ahmed, N. J. H. Hussien, and S. F. M. Yusoff, “Synthesis, Characterization and Biological activity of new Metal Complexes Derived From 4-Phenyl-3-thiosemicarbazide”, IJApSc, vol. 2, no. 4, pp. 52–63, Dec. 2025, doi: 10.69923/k2n0gm05.